Pumpkin seed has been traditionally used in herbal medicine throughout Europe as a remedy for urinary problems associated with an enlarged prostate gland and irritable bladder. It is approved by the German Commission E as a therapeutic agent for these conditions. The underlying mechanisms behind pumpkin seeds’ benefits are not entirely clear. From a nutritional standpoint, pumpkin seeds contain amino acid precursors for nitric oxide, which is needed to relax the urination muscles and decrease pressure in a full bladder.